Synthesis and antibacterial activity of C2-symmetric binaphthyl scaffolded amino acid derivatives
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چکیده
منابع مشابه
Synthesis and antibacterial activity of C2-symmetric binaphthyl scaffolded amino acid derivatives.
The synthesis of eleven novel antibacterial agents is reported. The structures are based on a C(2)-symmetric binaphthyl scaffold which holds two identical chains consisting of a short linker, a basic amino acid and a small hydrophobic side chain. Antibacterial activity is revealed for a number of derivatives down to an MIC of 2 μg/mL (2 μM) against Staphylococcus aureus--comparable to vancomyci...
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ژورنال
عنوان ژورنال: European Journal of Medicinal Chemistry
سال: 2011
ISSN: 0223-5234
DOI: 10.1016/j.ejmech.2011.06.024